Impurities

RITONAVIR Impurities

  • RITONAVIR - Impurity

  • Impurity: RITONAVIR - Impurity
  • Chemical Name: gama-(S)-Amino alpha- (1S)-(thiazoly methyloxycarbonyl)-amino-(2-phenylethyl)- (S)-benzene butanol
  • RITONAVIR - EP Impurity A (ureidovaline ritonavir)

  • Impurity: RITONAVIR - EP Impurity A (ureidovaline ritonavir)
  • Chemical Name: N-[[(methyl[[2-(1-methylethyl)-4-thiazoyl]methyl]amino]carbonyl]-L-valine
  • RITONAVIR - EP Impurity B (n-deacylvaline ritonavir)

  • Impurity: RITONAVIR - EP Impurity B (n-deacylvaline ritonavir)
  • Chemical Name: Thiazol-5-ylmethyl (2S,3S,5S)-5-[(S)-2-amino-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate
  • RITONAVIR - EP Impurity D (2,5-Thiazolylmethyl-dicarbamate)

  • Impurity: RITONAVIR - EP Impurity D (2,5-Thiazolylmethyl-dicarbamate)
  • Chemical Name: Bis(thiazol-5-ylmethyl) (2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyldicarbamate
  • RITONAVIR - EP Impurity E (Hydroxy-ritonavir)

  • Impurity: RITONAVIR - EP Impurity E (Hydroxy-ritonavir)
  • Chemical Name: Thiazol-5-ylmethyl (2S ,3S ,5S )-3-hydroxy-5-[(S )-2-(3-{[2-(2-hydroxypropan-2-yl)thiazol-4-yl]methyl}-3methylureido)3methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate
  • RITONAVIR - EP Impurity F (Hydantoinaminoalcohol)

  • Impurity: RITONAVIR - EP Impurity F (Hydantoinaminoalcohol)
  • Chemical Name: Thiazol-5-ylmethyl (2S,3S,5S)-3-hydroxy-5-[(S)-4-isopropyl-2,5-dioxoimidazolidin-1-yl]-1,6-diphenylhexan-2-ylcarbamate
  • RITONAVIR - EP Impurity G (Ritonavir Hydroperoxide)

  • Impurity: RITONAVIR - EP Impurity G (Ritonavir Hydroperoxide)
  • Chemical Name: Thiazol-5-ylmethyl (2S,3S,5S)-5-[(S)-2-(3-{[2-(2-hydroperoxypropan-2-yl)thiazol-4-yl]methyl}-3-methylureido)-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate
  • RITONAVIR - EP Impurity J (BOC-aminoalcohol)

  • Impurity: RITONAVIR - EP Impurity J (BOC-aminoalcohol)
  • Chemical Name: Thiazol-5-ylmethyl (2S,3S,5S)-( 5-t-butoxycarbonylamino)-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate
  • RITONAVIR - EP Impurity L (Oxazolidinone derivative)

  • Impurity: RITONAVIR - EP Impurity L (Oxazolidinone derivative)
  • Chemical Name: (S)-N-[(S)-1-[(4S,5S)-4-benzyl-2-oxooxazolidin-5-yl]-3-phenylpropan-2-yl]-2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamide
  • RITONAVIR - EP Impurity O (3-Epimer)

  • Impurity: RITONAVIR - EP Impurity O (3-Epimer)
  • Chemical Name: Thiazol-5-ylmethyl (2S,3R,5S)-3-hydroxy-5-[(S)-2-{3-[(2isopropylthiazol4yl)methyl]-3-methylureido}-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate
  • RITONAVIR - EP Impurity R (5-Epimer)

  • Impurity: RITONAVIR - EP Impurity R (5-Epimer)
  • Chemical Name: Thiazol-5-ylmethyl (2S,3S,5R)-3-hydroxy-5-[(S)-2-{3-[(2isopropylthiazol4yl)methyl]-3-methylureido}-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate
  • RITONAVIR - EP Impurity T (Divalinyl analog)

  • Impurity: RITONAVIR - EP Impurity T (Divalinyl analog)
  • Chemical Name: (2S)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl-2-[[methyl[[2-(1-methylethyl)thiazol-4-yl]mehtyl]carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl[[2-(1-methylethyl)thiazol-
  • RITONAVIR - EP Impurity U (O-Acyl ritonavir)

  • Impurity: RITONAVIR - EP Impurity U (O-Acyl ritonavir)
  • Chemical Name: (S)-[(5S,8S,10S,11S)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-15-(thiazol-5-yl)-14-oxa-2,4,7,12-tetraazapentadecan-10-yl] 2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-
  • Ritonavir Impurities

  • Impurity: Ritonavir Acetamido-alcohol
  • Chemical Name: Thiazol-5-ylmethyl (2S,3S,5S)-5-acetamido-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate
  • Ritonavir Impurities

  • Impurity: Ritonavir 2,5-Thiazolylmethyl-dicarbamate
  • Chemical Name: Bis(thiazol-5-ylmethyl) (2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyldicarbamate
  • Ritonavir Impurities

  • Impurity: Ritonavir Impurity-Hydroxy Ritonavir
  • Chemical Name: Thiazol-5-ylmethyl (2S ,3S ,5S )-3-hydroxy-5-[(S )-2-(3-{[2-(2-hydroxypropan-2-yl)thiazol-4-yl]methyl}-3-methylureido)-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate
  • Ritonavir Impurities

  • Impurity: Ritonavir Hydantoinaminoalcohol
  • Chemical Name: Thiazol-5-ylmethyl (2S,3S,5S)-3-hydroxy-5-[(S)-4-isopropyl-2,5-dioxoimidazolidin-1-yl]-1,6-diphenylhexan-2-ylcarbamate
  • Ritonavir Impurities

  • Impurity: Ritonavir Mixture of ureidovaline and N-decylvaline
  • Chemical Name: Ureidovaline is [N-methyl[(2-isopropyl-4-thiazolyl)methyl]amino]carbonyl –L-valine and N-deacylvaline ritonavir is thiazol-5-ylmethyl(2S,3S,5S)-5-[(S)-2-amino-3-methylbutanamido-3-hydroxy1,6-diphen
  • Ritonavir Impurities

  • Impurity: Ritonavir 4-Hydroxy Epimer
  • Chemical Name: Thiazol-5-ylmethyl (2S,4S,5S)-4-hydroxy-5-[(S)-2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate
  • Ritonavir Impurities

  • Impurity: Ritonavir Divalinyl Analog
  • Chemical Name: (2S,2S)-N,N-[(2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamide)
  • Ritonavir Impurities

  • Impurity: Ritonavir Valine Urea Analog
  • Chemical Name: (3S,4S,6S,10S,13S,15S,16S)-Bis(thiazol-5-ylmethyl)-4,15-dihydroxy-10-isopropyl-8,11-dioxo-3,6,13,16-tetrabenzyl-2,7,9,12,17-pentaazaoctadecanedioate
  • Ritonavir Impurities

  • Impurity: Ritonavir Ureidovaline isobutyl ester
  • Chemical Name: (S)-Isobutyl 2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methyl butanoate
  • Ritonavir Impurities

  • Impurity: Ritonavir Oxazolidinone derivative
  • Chemical Name: (S)-N-[(S)-1-[(4S,5S)-4-benzyl-2-oxooxazolidin-5-yl]-3-phenylpropan-2-yl]-2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamide
  • Ritonavir Impurities

  • Impurity: Ritonavir Ethyl analog
  • Chemical Name: Thiazol-5-ylmethyl)(2S,3S,5S)-5-[(S)-2-{3-[2-ethylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate

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