Impurities

Simvastatin Impurities

  • Simvastatin EP Impurity A

  • Impurity: Simvastatin EP Impurity A
  • Chemical Name: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8ahexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid (hydroxy acid)
  • Simvastatin EP Impurity B

  • Impurity: Simvastatin EP Impurity B
  • Chemical Name: (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-(acetyloxy)-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate (acetate ester)
  • Simvastatin EP Impurity C

  • Impurity: Simvastatin EP Impurity C
  • Chemical Name: (1S,3R,7S,8S,8aR)-3,7-dimethyl-8-[2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate (anhydrosimvastatin)
  • Simvastatin EP Impurity D

  • Impurity: Simvastatin EP Impurity D
  • Chemical Name: (2R,4R)-2-[[(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8ahexahydronaphthalen-1-yl]ethyl]-6-oxotetrahydro-2H-pyran-4-yl (3R,5R)-7-[(1S,2S,6R,8S,8aR)8[(2,2dimethylbutanoyl)o
  • Simvastatin EP Impurity E

  • Impurity: Simvastatin EP Impurity E
  • Chemical Name: (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2Hpyran- 2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2- methylbutanoate (lovastatin)
  • Simvastatin EP Impurity F

  • Impurity: Simvastatin EP Impurity F
  • Chemical Name: (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2Hpyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate (epilovastatin)
  • Simvastatin EP Impurity G

  • Impurity: Simvastatin EP Impurity G
  • Chemical Name: (1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-3-methylene-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
  • Simvastatin Anhydro sodium salt

  • Impurity: Simvastatin Anhydro sodium salt
  • Chemical Name: Simvastatin Anhydro sodium salt(IH)

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